ARG43861
anti-IGSF8 / CD316 antibody [8A12]
anti-IGSF8 / CD316 antibody [8A12] for Flow cytometry,IHC-Frozen sections,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognize IGSF8 / CD316. |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IHC-Fr, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 8A12 |
| 同位型 | IgG2a |
| 靶点名称 | IGSF8 / CD316 |
| 抗原物种 | Human |
| 抗原 | Human leukocytes |
| 偶联标记 | Un-conjugated |
| 別名 | IGSF8; Immunoglobulin Superfamily Member 8; CD81P3; EWI2; PGRL; CD316; Keratinocytes-Associated Transmembrane Protein 4; Glu-Trp-Ile EWI Motif-Containing Protein 2; Prostaglandin Regulatory-Like Protein; CD81 Partner 3; LIR-D1; EWI-2; KCT-4; Immunoglobulin Superfamily, Member 8; CD316 Antigen; IgSF8; KCT4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 4°C. Keep protected from prolonged exposure to light. Do not freeze. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 |
Swiss-port # Q969P0 Human Immunoglobulin superfamily member 8 |
|---|---|
| 基因名称 | IGSF8 |
| 全名 | Immunoglobulin Superfamily Member 8 |
| 背景介绍 | This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. |
| 生物功能 | May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. |
| 细胞定位 | Cell membrane; Membrane |
| 预测分子量 | 65 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein; Lipoprotein; Palmitate; Phosphoprotein |
检测图片 (1) Click the Picture to Zoom In
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ARG43861 anti-IGSF8 / CD316 antibody [8A12] FACS image
Flow Cytometry: Human whole blood stained with ARG43861 anti-IGSF8 / CD316 antibody [8A12] at 5 μg/ml.
