ARG22542
anti-IL10R subunit alpha antibody [1B1.3a]
anti-IL10R subunit alpha antibody [1B1.3a] for Flow cytometry and Mouse
概述
| 产品描述 | Rat Monoclonal antibody [1B1.3a] recognizes IL10R subunit alpha |
|---|---|
| 反应物种 | Ms |
| 不反应物种 | Hu |
| 应用 | FACS |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | 1B1.3a |
| 同位型 | IgG1 |
| 靶点名称 | IL10R subunit alpha |
| 抗原物种 | Mouse |
| 抗原 | Purified recombinant extracellular region of mouse CDw210a. |
| 偶联标记 | Un-conjugated |
| 別名 | IL-10R subunit alpha; CD210a; HIL-10R; Interleukin-10 receptor subunit alpha; IL-10R1; IL-10 receptor subunit alpha; IL10R; Interleukin-10 receptor subunit 1; IL-10R subunit 1; CDw210a; CDW210A; IL-10RA; CD antigen CD210; CD210 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | FACS: Due to low expression of CDw210a, sensitive staining techniques may be required. Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q61727 Mouse Interleukin-10 receptor subunit alpha |
|---|---|
| 基因名称 | Il10ra |
| 全名 | interleukin 10 receptor, alpha |
| 背景介绍 | The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009] |
| 生物功能 | Receptor for IL10; binds IL10 with a high affinity. [UniProt] |
| 预测分子量 | 63 kDa |
