ARG40783
anti-IL17RA antibody
anti-IL17RA antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IL17RA |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IL17RA |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 697-866 of Human IL17RA (intracellular domain) (NP_055154.3). |
| 偶联标记 | Un-conjugated |
| 別名 | Interleukin-17 receptor A; IL-17RA; IL-17 receptor A; hIL-17R; CANDF5; CDw217; IL17R; CD217; CD antigen CD217 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse lung | ||||
| 实际分子量 | ~ 100 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL17RA |
| 全名 | interleukin 17 receptor A |
| 背景介绍 | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] |
| 生物功能 | Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. [UniProt] |
| 细胞定位 | Membrane, Single-pass type I membrane protein, Secreted. [UniProt] |
| 预测分子量 | 96 kDa |
| 翻译后修饰 | Glycosylated. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG40783 anti-IL17RA antibody WB image
Western blot: 25 µg of Mouse lung lysate stained with ARG40783 anti-IL17RA antibody at 1:1000 dilution. Blocking buffer: 3% nonfat dry milk in TBST.
