ARG42438
anti-IL2 Receptor beta antibody [TU27]
anti-IL2 Receptor beta antibody [TU27] for Flow cytometry,Immunoprecipitation and Human
概述
| 产品描述 | Mouse Monoclonal antibody [TU27] recognizes IL2 Receptor beta |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IP |
| 特异性 | The mouse monoclonal antibody TU27 recognizes an extracellular epitope of CD122 (IL-2R beta), a 70-75 kDa type I transmembrane glycoprotein constitutively expressed by NK cells and a T cell subset, and upregulated upon activation. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | TU27 |
| 同位型 | IgG1, kappa |
| 靶点名称 | IL2 Receptor beta |
| 抗原物种 | Human |
| 抗原 | TL-Mor cell line. |
| 偶联标记 | Un-conjugated |
| 別名 | P70-75; IL-2RB; IL-2 receptor subunit beta; p75; Interleukin-2 receptor subunit beta; CD122; CD antigen CD122; High affinity IL-2 receptor subunit beta; IL-2R subunit beta; p70-75; IL15RB |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P14784 Human Interleukin-2 receptor subunit beta |
|---|---|
| 基因名称 | IL2RB |
| 全名 | interleukin 2 receptor, beta |
| 背景介绍 | The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016] |
| 生物功能 | Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 61 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG42438 anti-IL2 Receptor beta antibody [TU27] FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG42438 anti-IL2 Receptor beta antibody [TU27] at 4 µg/ml dilution, followed by APC-conjugated Goat anti-Mouse antibody.
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ARG42438 anti-IL2 Receptor beta antibody [TU27] FACS image
Flow Cytometry: Human CD3 negative lymphocytes stained with ARG42438 anti-IL2 Receptor beta antibody [TU27] at 4 µg/ml dilution, followed by APC-conjugated Goat anti-Mouse antibody. Samples were co-stained with anti-CD56 antibody [LT56] (FITC) at 10 µl / 100 µl of peripheral whole blood.
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ARG42438 anti-IL2 Receptor beta antibody [TU27] FACS image
Flow Cytometry: Separation of Human CD122 positive CD56 positive CD3 negative lymphocytes (red-filled) from neutrophil granulocytes (black-dashed). Human peripheral whole blood stained with ARG42438 anti-IL2 Receptor beta antibody [TU27] at 4 µg/ml dilution, followed by APC-conjugated Goat anti-Mouse antibody.
