ARG63041
anti-Insulin antibody [IN-05]
anti-Insulin antibody [IN-05] for ELISA,Functional study,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Radioimmunoassay and Human,Bovine,Pig
Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody [IN-05] recognizes Insulin |
|---|---|
| 反应物种 | Hu, Bov, Pig |
| 应用 | ELISA, FuncSt, ICC/IF, IHC-P, RIA |
| 特异性 | The clone IN-05 reacts with insulin, one of the major regulatory endocrine hormones of intermediate metabolism, normally secreted by the beta cells (a type of islet cells) of the pancreas; it is also present in tumors of B cell origin such as insulinoma. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | IN-05 |
| 同位型 | IgG1 |
| 靶点名称 | Insulin |
| 抗原物种 | Pig |
| 抗原 | Porcine insulin. |
| 偶联标记 | Un-conjugated |
| 別名 | IDDM; IDDM2; IDDM1; ILPR; MODY10; Insulin; IRDN |
应用说明
| 应用建议 |
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| 应用说明 | Functional studies: The clone IN-05 blocks binding of insulin to the receptor. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from ascites by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | INS |
| 全名 | insulin |
| 背景介绍 | Insulin and glucagon are pancreatic endocrine hormones secreted by islet cells within the pancreas. The stimulus for insulin secretion is a HIGH blood glucose. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. |
| 生物功能 | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 12 kDa |
克隆号文献
Transforming growth factor beta is a critical regulator of adult human islet plasticity.
IHC-P / Human
Murine hybridoma monoclonal antibodies against insulin: cross-reactivity with insulins of three species and blocking of insulin binding to its receptor.
