ARG64555
anti-LGP2 antibody
anti-LGP2 antibody for Western blot and Human
Gene Regulation antibody; Immune System antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes LGP2 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | LGP2 |
| 抗原物种 | Human |
| 抗原 | DFLQHCAENLSD |
| 偶联标记 | Un-conjugated |
| 別名 | D11LGP2; RIG-I-like receptor LGP2; Probable ATP-dependent RNA helicase DHX58; RIG-I-like receptor 3; Protein D11Lgp2 homolog; RLR-3; EC 3.6.4.13; D11lgp2e; Probable ATP-dependent helicase LGP2; LGP2; RLR |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q96C10 Human Probable ATP-dependent RNA helicase DHX58 |
|---|---|
| 基因名称 | DHX58 |
| 全名 | DEXH (Asp-Glu-X-His) box polypeptide 58 |
| 生物功能 | Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. [UniProt] |
| 研究领域 | Gene Regulation antibody; Immune System antibody |
| 预测分子量 | 77 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG64555 anti-LGP2 antibody WB image
Western Blot: Human Liver lysate (35 µg protein in RIPA buffer) stained with ARG64555 anti-LGP2 antibody at 0.3 µg/ml dilution.
