ARG65655
anti-Lamin B1 (isoform 1) antibody
anti-Lamin B1 (isoform 1) antibody for Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Controls and Markers antibody; Signaling Transduction antibody; NRF-2 Nuclear Localization Study antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes Lamin B1 (isoform 1) |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Cow, Pig |
| 应用 | WB |
| 特异性 | This antibody is expected to recognize isoform 1 (NP_005564.1) only. |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 靶点名称 | Lamin B1 (isoform 1) |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the internal region of Human Lamin B1 (C-KESDLNGAQIKLRE) |
| 偶联标记 | Un-conjugated |
| 別名 | LMN2; ADLD; Lamin-B1; LMN; LMNB |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | LMNB1 |
| 全名 | lamin B1 |
| 背景介绍 | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010] |
| 生物功能 | Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Controls and Markers antibody; Signaling Transduction antibody; NRF-2 Nuclear Localization Study antibody |
| 预测分子量 | 66.4 kDa (NP_005564.1) |
| 翻译后修饰 | B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. |
检测图片 (1) Click the Picture to Zoom In
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ARG65655 anti-Lamin B1 (isoform 1) antibody WB image
Western blot: 35 μg of Jurkat cell lysate stained with ARG65655 anti-Lamin B1 (isoform 1) antibody at 0.2 μg/ml dilution (1 hour incubation).
