ARG22106
anti-Ly6G + Ly6C antibody [RB6-8C5] (PE)
anti-Ly6G + Ly6C antibody [RB6-8C5] (PE) for Depletion,Flow cytometry,IHC-Frozen sections and Mouse
Mouse Inflammatory Cell Marker antibody; Neurophil Marker antibody; Mouse MDSC Marker antibody; Myeloid-derived suppressor cell antibody
概述
| 产品描述 | PE-conjugated Rat Monoclonal antibody [RB6-8C5] recognizes Ly6G + Ly6C |
|---|---|
| 反应物种 | Ms |
| 应用 | Depletion, FACS, IHC-Fr |
| 特异性 | This antibody recognizes the mouse Gr-1 antigen, a ~21 - 25 kDa GPI anchored cell surface protein bearing a single uPAR/Ly6 domain that belongs to the Ly-6 family of proteins (Lee et al. 2013). Clone RB6-8C5 reacts predominantly with the Ly-6G protein but weaker reactivity with the Ly-6C protein has been reported (Fleming et al. 1993). However, other observations dispute the cross-reactivity of clone RB6-8C5 with the Ly-6C protein with the alternative explanation that certain sub-populations of bone marrow cells simultaneously express both Ly-6C and Ly-6G (Nagendra et al. 2007). |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | RB6-8C5 |
| 同位型 | IgG2b, kappa |
| 靶点名称 | Ly6G + Ly6C |
| 抗原物种 | Mouse |
| 偶联标记 | PE |
| 別名 | Gr1; Gr-1; Ly-6G |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS, 0.1% Sodium azide and Sucrose. |
| 抗菌剂 | 0.1% Sodium azide |
| 稳定剂 | Sucrose |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Ly6g |
| 全名 | lymphocyte antigen 6 complex, locus G |
| 背景介绍 | Ly6G is a component of the myeloid differentiation antigen Gr-1, together with Ly6C. Ly6G is a good marker for detection of peripheral neutrophils. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. Physiological role of Ly6G remains still unclear. Its treatment with antibodies in vivo leads to neutropenia and has inhibitory effect on local immune responses. _x000D_ |
| 产品亮点 | Related products: Ly6 antibodies; Ly6 ELISA Kits; Ly6 Duos / Panels; Anti-Rat IgG secondary antibodies; Related news: New antibody panels and duos for Tumor immune microenvironment Exploring Antiviral Immune Response Anti-SerpinB9 therapy, a new strategy for cancer therapy |
| 研究领域 | Mouse Inflammatory Cell Marker antibody; Neurophil Marker antibody; Mouse MDSC Marker antibody; Myeloid-derived suppressor cell antibody |
| 预测分子量 | 12 kDa |
检测图片 (6) Click the Picture to Zoom In
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ARG22106 anti-Ly6G + Ly6C antibody [RB6-8C5] (PE) FACS image
Flow Cytometry: BALB/c Mouse splenocytes stained with ARG62717 anti-CD11b antibody [M1/70] (FITC) and ARG22106 anti-Ly6G + Ly6C antibody [RB6-8C5] (PE).
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ARG22106 anti-Ly6G + Ly6C antibody [RB6-8C5] (PE) FACS image
Flow Cytometry: C57BL/6 Mouse bone marrow cells stained with ARG22106 anti-Ly6G + Ly6C antibody [RB6-8C5] (PE) and ARG20850 anti-CD19 antibody [6D5] (FITC).
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