ARG42181
anti-MEX3C antibody
anti-MEX3C antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Goat Polyclonal antibody recognizes MEX3C |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow, Dog, Pig |
| 应用 | IHC-P |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MEX3C |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the internal region of Human MEX3C. (C-TPRLSPTFPESIEH) (NP_057710.3) |
| 偶联标记 | Un-conjugated |
| 別名 | EC 6.3.2.-; MEX-3C; RNF194; RING finger and KH domain-containing protein 2; RNA-binding E3 ubiquitin-protein ligase MEX3C; BM-013; RKHD2; RING finger protein 194 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q5U5Q3 Human RNA-binding E3 ubiquitin-protein ligase MEX3C |
|---|---|
| 基因名称 | MEX3C |
| 全名 | mex-3 RNA binding family member C |
| 背景介绍 | This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009] |
| 生物功能 | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation. [UniProt] |
| 预测分子量 | 69 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42181 anti-MEX3C antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG42181 anti-MEX3C antibody at 5 µg/ml dilution followed by AP-staining.
