ARG44871
anti-MGRN1 antibody
anti-MGRN1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes MGRN1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | MGRN1 |
| 抗原物种 | Human |
| 抗原表位 | GVEDIDIQAN SAYRYPPKSG NYFASHFFMG GEKFDTPHPE GYLFGENMDL NFLGSRPVQF PYVTPAPHEP VKTLRSLVNI RKDSLRLVRY KDDADSPTED GDKPRVLYSL EFTFDADARV AITIYCQASE EFLNGRAVYS PKSPSLQSET VHYKRGVSQQ FSLPSFKIDF SEWKDDELNF DLDRGVFPVV IQAVVDEGDV VEVTGHAHVL LAAFEKHMDG SFSVKPLKQK QIVDRVSYLL QEIYGIENKN NQETKPSDDE |
| 偶联标记 | Un-conjugated |
| 別名 | MGRN1; Mahogunin Ring Finger 1; RNF156; KIAA0544; Mahogunin Ring Finger 1, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase MGRN1; E3 Ubiquitin-Protein Ligase MGRN1; Mahogunin RING Finger Protein 1; RING Finger Protein 156; Probable E3 Ubiquitin-Protein Ligase MGRN1; Mahogunin, Ring Finger 1; EC 2.3.2.27; EC 6.3.2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MGRN1 |
| 全名 | Mahogunin Ring Finger 1 |
| 背景介绍 | Enables ubiquitin-protein transferase activity. Involved in endosome to lysosome transport; negative regulation of signal transduction; and protein monoubiquitination. Located in several cellular components, including early endosome; endoplasmic reticulum; and nucleus. [provided by Alliance of Genome Resources, Apr 2022] |
| 生物功能 | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling. [UniProt] |
| 细胞定位 | Cell membrane, Cytoplasm, Endosome, Membrane, Nucleus. [UniProt] |
| 翻译后修饰 | Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG44871 anti-MGRN1 antibody IHC-P image
Immunohistochemistry: Human brain stained with ARG44871 anti-MGRN1 antibody at 5 µg/mL dilution.
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ARG44871 anti-MGRN1 antibody IP image
Immunoprecipitation: HEK293 lysate immunoprecipitated with 2.5 µg of ARG44871 anti-MGRN1 antibody.
