ARG66660
anti-MMP11 antibody
anti-MMP11 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MMP11 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MMP11 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within aa. 30-110 of Human MMP11. |
| 偶联标记 | Un-conjugated |
| 別名 | SL-3; STMY3; EC 3.4.24.-; ST3; Matrix metalloproteinase-11; MMP-11; Stromelysin-3 |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: High-pressure and temperature Tris/EDTA buffer (pH 8.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 实际分子量 | ~ 65 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MMP11 |
| 全名 | matrix metallopeptidase 11 |
| 背景介绍 | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008] |
| 生物功能 | May play an important role in the progression of epithelial malignancies. [UniProt] |
| 细胞定位 | Secreted, extracellular space, extracellular matrix. [UniProt] |
| 预测分子量 | 55 kDa |
| 翻译后修饰 | The precursor is cleaved by a furin endopeptidase. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG66660 anti-MMP11 antibody ICC/IF image
Immunofluorescence: A549 cells stained with ARG66660 anti-MMP11 antibody. The picture on the right is blocked with the synthetic peptide.
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ARG66660 anti-MMP11 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG66660 anti-MMP11 antibody at 1:100 dilution, overnight at 4°C. Antigen Retrieval: High-pressure and temperature Tris/EDTA buffer (pH 8.0). Negative control (right): Antibody was pre-absorbed by immunogen peptide.
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ARG66660 anti-MMP11 antibody WB image
Western blot: A549 cell lysate stained with ARG66660 anti-MMP11 antibody at 1:500 dilution.
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ARG66660 anti-MMP11 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human breast carcinoma tissue stained with ARG66660 anti-MMP11 antibody. The picture on the right is blocked with the synthetic peptide.
