概述

产品描述	Rabbit Polyclonal antibody recognizes MMP12
反应物种	Hu, Ms, Rat
应用	IHC-P, IP, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	MMP12
抗原物种	Human
抗原	Synthetic peptide derived from Human MMP12.
偶联标记	Un-conjugated
別名	ME; EC 3.4.24.65; Macrophage metalloelastase; MMP-12; hME; MME; HME; Matrix metalloproteinase-12; Macrophage elastase

应用说明

应用建议	应用 推荐稀释比 IHC-P 1:50 - 1:200 IP 1:30 WB 1:1000 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	WI-38

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 117033 Rat MMP12 GeneID: 17381 Mouse MMP12 GeneID: 4321 Human MMP12 Swiss-port # P34960 Mouse Macrophage metalloelastase Swiss-port # P39900 Human Macrophage metalloelastase Swiss-port # Q63341 Rat Macrophage metalloelastase More
基因名称	MMP12
全名	matrix metallopeptidase 12
背景介绍	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
生物功能	May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. [UniProt]
细胞定位	Secreted, extracellular space, extracellular matrix. [UniProt]
预测分子量	54 kDa

检测图片 (1) Click the Picture to Zoom In