ARG40422
anti-MMP17 / MT4-MMP antibody
anti-MMP17 / MT4-MMP antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MMP17 / MT4-MMP |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Cow, Hrs |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MMP17 / MT4-MMP |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide from Human MMP17 / MT4-MMP. (located within the following region: YPQSTARDWLVCGDSQADGSVAAGVDAAEGPRAPPGQHDQSRSEDGYEVC) |
| 偶联标记 | Un-conjugated |
| 別名 | Membrane-type matrix metalloproteinase 4; MT-MMP 4; MT4-MMP; EC 3.4.24.-; MT4MMP; MTMMP4; MMP-17; Membrane-type-4 matrix metalloproteinase; Matrix metalloproteinase-17 |
应用说明
| 预测反应性说明 | Predicted Homology Based On Immunogen Sequence: Cow: 79%; Horse: 93% | ||||
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| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.09% (w/v) Sodium azide and 2% Sucrose. |
| 抗菌剂 | 0.09% (w/v) Sodium azide |
| 稳定剂 | 2% Sucrose |
| 浓度 | Batch dependent: 0.5 - 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MMP17 |
| 全名 | matrix metallopeptidase 17 (membrane-inserted) |
| 背景介绍 | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq, Jul 2008] |
| 生物功能 | Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. [UniProt] |
| 细胞定位 | Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. [UniProt] |
| 预测分子量 | 67 kDa |
| 翻译后修饰 | The precursor is cleaved by a furin endopeptidase. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG40422 anti-MMP17 / MT4-MMP antibody WB image
Western blot: 50 ug of Jurkat whole cell lysate stained with ARG40422 anti-MMP17 / MT4-MMP antibody at 1 ug/ml dilution.
