ARG55969
anti-MUC2 / Mucin 2 antibody [CCP58]
anti-MUC2 / Mucin 2 antibody [CCP58] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody [CCP58] recognizes MUC2 / Mucin 2 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | CCP58 |
| 同位型 | IgG1, kappa |
| 靶点名称 | MUC2 / Mucin 2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide from Human MUC2 protein. (KYPTTTPISTTTMVTPTPTPTGTQTPTTT) |
| 偶联标记 | Un-conjugated |
| 別名 | MUC-2; MLP; Intestinal mucin-2; SMUC; Mucin-2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Tris-HCl buffer (pH 10.0) for 10-20 min, followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MUC2 |
| 全名 | mucin 2, oligomeric mucus/gel-forming |
| 背景介绍 | This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008] |
| 生物功能 | Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. [UniProt] |
| 细胞定位 | Cytoplasmic and cell surface |
| 产品亮点 | Related products: MUC2 antibodies; Anti-Mouse IgG secondary antibodies; Related news: More than a biomarker, CA19-9 is a therapeutic target of pancreatic cancer |
| 预测分子量 | 540 kDa |
| 翻译后修饰 | O-glycosylated. May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria. At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway. |
检测图片 (2) Click the Picture to Zoom In
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ARG55969 anti-MUC2 / Mucin 2 antibody [CCP58] IHC-P image
Immunohistochemistry: Formalin-fixed, paraffin-embedded normal Human intestine stained with ARG55969 anti-MUC2 / Mucin 2 antibody [CCP58].
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ARG55969 anti-MUC2 / Mucin 2 antibody [CCP58] IHC-P image
Immunohistochemistry: Formalin-fixed, paraffin-embedded Human colon carcinoma stained with ARG55969 anti-MUC2 / Mucin 2 antibody [CCP58].
