ARG64239
anti-Neuregulin 3 antibody
anti-Neuregulin 3 antibody for Western blot and Human,Mouse,Rat
Cancer antibody; Neuroscience antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes Neuregulin 3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 预测物种 | Dog |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Neuregulin 3 |
| 抗原物种 | Human |
| 抗原 | C-RNEIQRDSALTK |
| 偶联标记 | Un-conjugated |
| 別名 | Pro-NRG3; pro-NRG3; Pro-neuregulin-3, membrane-bound isoform; HRG3; NRG-3 |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O35181 Mouse Pro-neuregulin-3, membrane-bound isoform Swiss-port # P56975 Human Pro-neuregulin-3, membrane-bound isoform |
|---|---|
| 背景介绍 | This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009] |
| 研究领域 | Cancer antibody; Neuroscience antibody |
| 预测分子量 | 78 kDa |
| 翻译后修饰 | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated. |
检测图片 (1) Click the Picture to Zoom In
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ARG64239 anti-Neuregulin 3 antibody WB image
Western Blot: Human Brain (Cerebellum) lysate (35 µg protein in RIPA buffer) stained with ARG64239 anti-Neuregulin 3 antibody at 0.3 µg/ml dilution.
