ARG43872
anti-OLR1 / LOX1 antibody [15C4] (PE)
anti-OLR1 / LOX1 antibody [15C4] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody recognize OLR1 / LOX1. |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 15C4 |
| 同位型 | IgG2a kappa |
| 靶点名称 | OLR1 / LOX1 |
| 抗原物种 | Human |
| 抗原 | Human OLR1 / LOX1 fusion protein. |
| 偶联标记 | PE |
| 別名 | Lectin-like oxidized LDL receptor 1; Lectin-type oxidized LDL receptor 1; LOX-1; CLEC8A; SLOX1; LOXIN; hLOX-1; Oxidized low-density lipoprotein receptor 1; Lectin-like oxLDL receptor 1; C-type lectin domain family 8 member A; Ox-LDL receptor 1; LOX1; SCARE1 |
应用说明
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 4°C. Keep protected from prolonged exposure to light. Do not freeze. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 |
Swiss-port # P78380 Human Oxidized low-density lipoprotein receptor 1 |
|---|---|
| 基因名称 | OLR1 |
| 全名 | oxidized low density lipoprotein (lectin-like) receptor 1 |
| 背景介绍 | This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] |
| 生物功能 | Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. [UniProt] |
| 细胞定位 | Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation |
| 预测分子量 | 31 kDa |
| 翻译后修饰 | The intrachain disulfide-bonds prevent N-glycosylation at some sites. N-glycosylated. |
