ARG64260
anti-Ogg1 antibody
anti-Ogg1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
Cancer antibody; Gene Regulation antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes Ogg1 |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Ms |
| 应用 | IHC-P, WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Ogg1 |
| 抗原物种 | Mouse |
| 抗原 | C-HPKTSQAKGPSPLANK |
| 偶联标记 | Un-conjugated |
| 別名 | EC 4.2.99.18; N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase; HOGG1; MUTM; OGH1; AP lyase; HMMH; apurinic or apyrimidinic site; EC 3.2.2.- |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Ogg1 |
| 全名 | 8-oxoguanine DNA-glycosylase 1 |
| 背景介绍 | This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008] |
| 生物功能 | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. [UniProt] |
| 研究领域 | Cancer antibody; Gene Regulation antibody |
| 预测分子量 | 39 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG64260 anti-Ogg1 antibody WB image
Western Blot: Rat Spleen lysate (35 µg protein in RIPA buffer) stained with ARG64260 anti-Ogg1 antibody at 0.1 µg/ml dilution.
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ARG64260 anti-Ogg1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG64260 anti-Ogg1 antibody at 5 µg/ml dilution followed by AP-staining.
