ARG66828
anti-Olig2 antibody [SQab20240]
anti-Olig2 antibody [SQab20240] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant Rabbit Monoclonal antibody [SQab20240] recognizes Olig2 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab20240 |
| 同位型 | IgG |
| 靶点名称 | Olig2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human Olig2. |
| 偶联标记 | Un-conjugated |
| 別名 | bHLHb1; Class E basic helix-loop-helix protein 19; Class B basic helix-loop-helix protein 1; Oligo2; bHLHe19; Oligodendrocyte transcription factor 2; BHLHB1; Protein kinase C-binding protein 2; OLIGO2; Protein kinase C-binding protein RACK17; PRKCBP2; RACK17 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C - 25°C) for 30 minutes. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q13516 Human Oligodendrocyte transcription factor 2 |
|---|---|
| 基因名称 | OLIG2 |
| 全名 | oligodendrocyte lineage transcription factor 2 |
| 背景介绍 | This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008] |
| 生物功能 | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. [UniProt] |
| 细胞定位 | Nucleus. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. [UniProt] |
| 预测分子量 | 32 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG66828 anti-Olig2 antibody [SQab20240] IHC-P image
Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded Human brain tissue. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). The tissue section was stained with ARG66828 anti-Olig2 antibody [SQab20240].
