ARG42801
anti-P70 S6 Kinase beta antibody
anti-P70 S6 Kinase beta antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes P70 S6 Kinase beta |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | P70 S6 Kinase beta |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human P70 S6 Kinase beta. |
| 偶联标记 | Un-conjugated |
| 別名 | S6K-beta2; p70 ribosomal S6 kinase beta; Ribosomal protein S6 kinase beta-2; S6 kinase-related kinase; S6K-beta-2; p70-beta; p70 S6K-beta; p70 S6 kinase beta; p70S6Kb; STK14B; p70 S6KB; p70-S6K 2; P70-beta-1; P70-beta-2; S6K2; SRK; P70S6K2; KLS; Serine/threonine-protein kinase 14B; S6K-beta; P70-beta; p70(S6K)-beta; 70 kDa ribosomal protein S6 kinase 2; EC 2.7.11.1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | HeLa | ||||||||||
| 实际分子量 | ~ 57 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 浓度 | Batch dependent |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UBS0 Human Ribosomal protein S6 kinase beta-2 Swiss-port # Q9Z1M4 Mouse Ribosomal protein S6 kinase beta-2 |
|---|---|
| 基因名称 | RPS6KB2 |
| 全名 | ribosomal protein S6 kinase, 70kDa, polypeptide 2 |
| 背景介绍 | This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015] |
| 生物功能 | Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. [UniProt] |
| 预测分子量 | 53 kDa |
| 翻译后修饰 | Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42801 anti-P70 S6 Kinase beta antibody WB image
Western blot: HeLa cell lysate stained with ARG42801 anti-P70 S6 Kinase beta antibody at 1:1000 dilution.
