ARG10507
anti-PAPP A antibody [4G11]
anti-PAPP A antibody [4G11] for ELISA,Western blot and Human
Cell Biology and Cellular Response antibody
概述
| 产品描述 | Mouse Monoclonal antibody [4G11] recognizes PAPP A |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, WB |
| 特异性 | Human PAPP A antigen purified from placental blood (heterotetrameric complex, consisting of PAPP A subunits and proMBP subunits). |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 4G11 |
| 同位型 | IgG2a |
| 靶点名称 | PAPP A |
| 抗原物种 | Human |
| 抗原 | Balb/c mice immunized with purified human PAPP A / proMBP (heterotetrameric PAPP A, htPAPP A) complex |
| 偶联标记 | Un-conjugated |
| 別名 | DIPLA1; Pappalysin-1; Insulin-like growth factor-dependent IGF-binding protein 4 protease; PAPPA1; IGFBP-4ase; Pregnancy-associated plasma protein A; PAPA; IGF-dependent IGFBP-4 protease; EC 3.4.24.79; PAPP-A; ASBABP2 |
应用说明
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A affinity purified. |
| 缓冲液 | PBS (pH 7.2) and 0.1% Sodium azide |
| 抗菌剂 | 0.1 % Sodium azide |
| 浓度 | 1.0-2.0 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PAPPA |
| 全名 | pregnancy-associated plasma protein A, pappalysin 1 |
| 背景介绍 | This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008] |
| 生物功能 | Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. [UniProt] |
| 产品亮点 | Related Antibody Duos and Panels: ARG30198 PAPP A ELISA Antibody Duo Related products: PAPP A antibodies; PAPP A ELISA Kits; PAPP A Duos / Panels; Anti-Mouse IgG secondary antibodies; |
| 研究领域 | Cell Biology and Cellular Response antibody |
| 预测分子量 | 181 kDa |
| 翻译后修饰 | There appear to be no free sulfhydryl groups. |
