ARG67010
anti-PAX6 antibody
anti-PAX6 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PAX6 |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PAX6 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the middle region of Human PAX6. |
| 偶联标记 | Un-conjugated |
| 別名 | MGDA; Aniridia type II protein; AN; Oculorhombin; Paired box protein Pax-6; AN2; WAGR; FVH1; D11S812E |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | ~ 47 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 100 mM Tris Glycine (pH 7.0), 0.025% ProClin 300, 1%BSA and 20% Glycerol. |
| 抗菌剂 | 0.025% ProClin 300 |
| 稳定剂 | 1%BSA and 20% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PAX6 |
| 全名 | paired box 6 |
| 背景介绍 | This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015] |
| 生物功能 | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes. [UniProt] |
| 预测分子量 | 47 kDa |
| 翻译后修饰 | Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG67010 anti-PAX6 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded mouse tissue stained with ARG67010 anti-PAX6 antibody at 1:400 dilution.
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ARG67010 anti-PAX6 antibody WB image
Western blot: 293T stained with ARG67010 anti-PAX6 antibody at 10% SDS-PAGE.
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ARG67010 anti-PAX6 antibody ICC/IF
Immunocytochemistry: Formalin-fixed and paraffin-embedded prostate cell stained with ARG67010 anti-PAX6 antibody at 1:300 dilution.
