ARG45078
anti-PKC theta antibody [M217]
anti-PKC theta antibody [M217] for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [M217] recognizes PKC theta |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | M217 |
| 同位型 | IgG2a |
| 靶点名称 | PKC theta |
| 抗原物种 | Mouse |
| 抗原 | Clone (M217) was generated from a recombinant mouse PKCθ protein that included amino acids residues in the N-terminal region. This sequence is conserved in human and rat PKCθ, and has low homology to other PKC family members. |
| 偶联标记 | Un-conjugated |
| 別名 | PRKCQ; Protein Kinase C Theta ; Protein Kinase C Theta Type; EC 2.7.11.13; NPKC-Theta; PRKCT; Protein Kinase C, Theta; EC 2.7.11 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A Purified. |
| 缓冲液 | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| 稳定剂 | 50% Glycerol and 0.1 % BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PRKCQ |
| 全名 | Protein Kinase C Theta |
| 背景介绍 | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008] |
| 生物功能 | Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking. [Uniprot] |
| 细胞定位 | Cell membrane, Cytoplasm, Membrane. [Uniprot] |
| 预测分子量 | 82 kDa |
| 翻译后修饰 | Phosphoprotein. [Uniprot] |
