ARG55270
anti-PRDM1 / Blimp 1 antibody
anti-PRDM1 / Blimp 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Gene Regulation antibody; Immune System antibody
参考文献1
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PRDM1 / Blimp 1 |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PRDM1 / Blimp 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide (17 aa) within aa. 100-150 of Human PRDM1 / Blimp1. |
| 偶联标记 | Un-conjugated |
| 別名 | Beta-interferon gene positive regulatory domain I-binding factor; PR domain zinc finger protein 1; BLIMP-1; BLIMP1; PRDI-binding factor 1; PR domain-containing protein 1; EC 2.1.1.-; PRDI-BF1; Positive regulatory domain I-binding factor 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse Lung Tissue Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PRDM1 |
| 全名 | PR domain containing 1, with ZNF domain |
| 背景介绍 | This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008] |
| 生物功能 | Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. [UniProt] |
| 研究领域 | Gene Regulation antibody; Immune System antibody |
| 预测分子量 | 92 kDa |
| 翻译后修饰 | Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation. Ubiquitinated by the SCF(FBXO11) complex, leading to its degradation by the proteasome. |
检测图片 (2) Click the Picture to Zoom In
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ARG55270 anti-PRDM1 / Blimp 1 antibody IHC-P image
Immunohistochemistry: Mouse lung tissue stained with ARG55270 anti-PRDM1 / Blimp 1 antibody at 5 µg/ml dilution.
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ARG55270 anti-PRDM1 / Blimp 1 antibody WB image
Western blot: Mouse lung tissue lysate stained with ARG55270 anti-PRDM1 / Blimp 1 antibody.
文献引用
Analysis of Blimp-1 and PD-1/PD-L1 Immune Checkpoint in an Autoimmune Thyroiditis Animal Model.
WB, IHC-P / Mouse
