ARG43855
anti-Perforin antibody [dG9] (PE-Cyanine 7)
anti-Perforin antibody [dG9] (PE-Cyanine 7) for Flow cytometry and Human
概述
| 产品描述 | PE-Cyanine 7-conjugated Mouse Monoclonal antibody human Perforin |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Cow |
| 应用 | FACS |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | dG9 |
| 同位型 | IgG2b kappa |
| 靶点名称 | Perforin |
| 抗原物种 | Human |
| 抗原 | Human YT lymphoma cell line |
| 偶联标记 | PE-Cyanine 7 |
| Protein Full name | Perforin-1 |
| 別名 | PRF1; Perforin 1; PFP; P1; HPLH2; Perforin 1 (Pore Forming Protein); Lymphocyte Pore-Forming Protein; Perforin-1; Cytolysin; Perforin 1 (Preforming Protein); Perforin |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein-A affinity chromatography |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 4°C. Keep protected from prolonged exposure to light. Do not freeze. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PRF1 |
| 全名 | Perforin 1 |
| 背景介绍 | This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. |
| 生物功能 | Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells. |
| 细胞定位 | Cell membrane, Endosome, Lysosome, Membrane, Secreted |
| 预测分子量 | 61 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein |
检测图片 (1) Click the Picture to Zoom In
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ARG43855 anti-Perforin antibody [dG9] (PE-Cyanine 7) FACS image
Flow Cytometry: Human whole blood stained with ARG43855 anti-Perforin antibody [dG9] (PE-Cyanine 7) at 4 μg.
