概述

产品描述	Rabbit Polyclonal antibody recognizes RAP80
反应物种	Hu
应用	IHC-P, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	RAP80
抗原物种	Human
抗原	Synthetic peptide derived from Human RAP80.
偶联标记	Un-conjugated
別名	RAP80; Retinoid X receptor-interacting protein 110; Receptor-associated protein 80; Ubiquitin interaction motif-containing protein 1; X2HRIP110; BRCA1-A complex subunit RAP80

应用说明

应用建议	应用 推荐稀释比 IHC-P 1:50 - 1:200 WB 1:1000 - 1:5000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	293T
实际分子量	~ 80 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 51720 Human UIMC1 Swiss-port # Q96RL1 Human BRCA1-A complex subunit RAP80
基因名称	UIMC1
全名	ubiquitin interaction motif containing 1
生物功能	Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. [UniProt]
细胞定位	Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). [UniProt]
预测分子量	80 kDa
翻译后修饰	Sumoylated. Phosphorylated upon DNA damage by ATM or ATR. [UniProt]

检测图片 (1) Click the Picture to Zoom In