概述

产品描述	Mouse Monoclonal antibody recognizes RNF135
反应物种	Hu
应用	WB
宿主	Mouse
克隆	Monoclonal
同位型	IgG1
靶点名称	RNF135
抗原物种	Human
抗原表位	HLRKNTLLQD LADKYRRAAR EIQAGSDPAH CPCPGSSSLS SAAARPRRRP ELQRVAVEKS ITEVAQELTE LVEHLVDIVR SLQNQRPLSE SGPDNELSIL GKAFSSGVDL SMASPKLVTS DTAAGKIRDI LHDLEEIQEK LQESVTWKEA PEAQMQGELL
偶联标记	Un-conjugated
別名	RNF135; Ring Finger Protein 135; Riplet; RING Finger Protein Leading To RIG-I Activation; RING-Type E3 Ubiquitin Transferase RNF135; E3 Ubiquitin-Protein Ligase RNF135; RIG-I E3 Ubiquitin Ligase; MGC13061; REUL; RING Finger Protein 135; EC 2.3.2.27; MMFD; L13

应用说明

应用建议	应用 推荐稀释比 WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Protein A purification
缓冲液	PBS with 0.09% sodium azide
抗菌剂	0.09% sodium azide
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 84282 Human RNF135 Swiss-port # Q8IUD6 Human E3 ubiquitin-protein ligase RNF135
基因名称	RNF135
全名	Ring Finger Protein 135
背景介绍	The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
生物功能	This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway. [UniProt]
细胞定位	Cytoplasm
预测分子量	48 kDa

检测图片 (1) Click the Picture to Zoom In