ARG43819
anti-SAPK / JNK antibody
anti-SAPK / JNK antibody for Immunoprecipitation,Western blot and Human,Mouse,Rat,Hamster
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SAPK / JNK |
|---|---|
| 反应物种 | Hu, Ms, Rat, Hm |
| 应用 | IP, WB |
| 特异性 | Human,Mouse,Rat,Hamster |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MAPK8 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of human JNK. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Mitogen-activated protein kinase 8 |
| 別名 | MAPK8; Mitogen-Activated Protein Kinase 8; SAPK1; JNK1; PRKM8; JNK; Stress-Activated Protein Kinase 1c; C-Jun N-Terminal Kinase 1; JUN N-Terminal Kinase; MAP Kinase 8; EC 2.7.11.24; JNK-46; SAPK1c; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase 1; JNK21B1/2; EC 2.7.11; JNK1A2; SAPK1C; MAPK 8 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 46-54 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | Tris-Glycine, 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MAPK8 |
| 全名 | Mitogen-Activated Protein Kinase 8 |
| 背景介绍 | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016] |
| 生物功能 | JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. [UniProt] |
| 细胞定位 | Cytoplasm, Nucleus, Synapse. [UniProt] |
| 预测分子量 | 48 kDa |
| 翻译后修饰 | Phosphoprotein, S-nitrosylation. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG43819 anti-SAPK / JNK antibody WB image
Western blot: Jurkat, Rat Brain, C6, CHO-K1 and HeLa cells stained with ARG43819 anti-SAPK / JNK antibody at 1:500 dilution.
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ARG43819 anti-SAPK / JNK antibody WB image
Western blot: Mouse Brain stained with ARG43819 anti-SAPK / JNK antibody at 1:500 dilution.
