ARG56196
anti-SHBG antibody [SHBG/245]
anti-SHBG antibody [SHBG/245] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody [SHBG/245] recognizes SHBG |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | SHBG/245 |
| 同位型 | IgG1 |
| 靶点名称 | SHBG |
| 抗原物种 | Human |
| 抗原 | Recombinant full-length human SHBG protein. |
| 偶联标记 | Un-conjugated |
| 別名 | SHBG; SBP; Testosterone-estradiol-binding globulin; Sex hormone-binding globulin; Sex steroid-binding protein; ABP; TeBG; Testis-specific androgen-binding protein; Testosterone-estrogen-binding globulin; TEBG |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Tris buffer with 1 mM EDTA (pH 9.0) for 10-20 min, followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SHBG |
| 全名 | sex hormone-binding globulin |
| 背景介绍 | This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| 生物功能 | Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. [UniProt] |
| 细胞定位 | Cytoplasmic & extracellular (secreted) |
| 预测分子量 | 44 kDa |
| 翻译后修饰 | Variant Asn-356 contains one N-linked (GlcNAc...) at position 356. |
检测图片 (1) Click the Picture to Zoom In
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ARG56196 anti-SHBG antibody [SHBG/245] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human testicular carcinoma stained with ARG56196 anti-SHBG antibody [SHBG/245].
