ARG67147
anti-SNAIL antibody
anti-SNAIL antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Gene Regulation antibody; Neuroscience antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SNAIL |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Mk |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SNAIL |
| 抗原物种 | Human |
| 抗原 | Synthesized peptide corresponding to a.a. 215-264 of Human SNAIL. |
| 偶联标记 | Un-conjugated |
| 別名 | SNAI1; Snail Family Transcriptional Repressor 1; SNAH; SLUGH2; SNAIL1; SNAIL; SNA; Snail Family Zinc Finger 1; Zinc Finger Protein SNAI1; Protein Snail Homolog 1; Protein Sna; Snail 1 (Drosophila Homolog), Zinc Finger Protein; Snail Homolog 1 (Drosophila); Snail 1 Zinc Finger Protein; Snail 1 Homolog; Snail Homolog 1; DJ710H13.1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% glycerol and 0.5% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SNAI1 |
| 全名 | Snail Family Transcriptional Repressor 1 |
| 背景介绍 | The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008] |
| 生物功能 | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. [UniProt] |
| 细胞定位 | Cytoplasm, Nucleus. [UniProt] |
| 产品亮点 | Related products: SNAIL antibodies; Anti-Rabbit IgG secondary antibodies; Related news: Understanding Your Cells: Choose the right markers SM5-1, a promising immunotherapy for Hepatocellular Carcinoma (HCC) |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Gene Regulation antibody; Neuroscience antibody |
| 预测分子量 | 29 kDa |
| 翻译后修饰 | ADP-ribosylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG67147 anti-SNAIL antibody IHC-P image
Immunohistochemistry: Human small intestinal carcinoma stained with ARG67147 anti-SNAIL antibody at 1:200 dilution.
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ARG67147 anti-SNAIL antibody WB image
Western blot: 3T3 stained with ARG67147 anti-SNAIL antibody at 1:1000 dilution.
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ARG67147 anti-SNAIL antibody IHC-P image
Immunohistochemistry: Rat spleen stained with ARG67147 anti-SNAIL antibody at 1:200 dilution.
