ARG40186
anti-Serotonin Transporter antibody
anti-Serotonin Transporter antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Serotonin Transporter |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Serotonin Transporter |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within aa. 500 to the C-terminus of Human Serotonin Transporter (NP_001036.1). |
| 偶联标记 | Un-conjugated |
| 別名 | SERT; 5HTT; SERT1; Sodium-dependent serotonin transporter; hSERT; 5-HTTLPR; Solute carrier family 6 member 4; HTT; 5-HTT; 5HT transporter; OCD1 |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | U-251MG | ||||||
| 实际分子量 | 69 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SLC6A4 |
| 全名 | solute carrier family 6 (neurotransmitter transporter), member 4 |
| 背景介绍 | This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008] |
| 生物功能 | Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. [UniProt] |
| 细胞定位 | Cell membrane, Endomembrane system, Endosome membrane, Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 70 kDa |
| 翻译后修饰 | Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms. Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation. Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
-
ARG40186 anti-Serotonin Transporter antibody WB image
Western blot: 25 µg of U-251MG cell lysate stained with ARG40186 anti-Serotonin Transporter antibody at 1:1000 dilution.
-
ARG40186 anti-Serotonin Transporter antibody WB image
Western blot: 25 µg of Mouse lung lysate stained with ARG40186 anti-Serotonin Transporter antibody at 1:1000 dilution.
