ARG41841
anti-Syntenin 1 antibody
anti-Syntenin 1 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Syntenin 1 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Syntenin 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human Syntenin 1. |
| 偶联标记 | Un-conjugated |
| 別名 | SYCL; MDA-9; MDA9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Syndecan-binding protein 1; TACIP18; Scaffold protein Pbp1; ST1; Syntenin-1; Melanoma differentiation-associated protein 9 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||||
| 阳性对照 | HeLa | ||||||||||||
| 实际分子量 | ~ 32 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SDCBP |
| 全名 | syndecan binding protein (syntenin) |
| 背景介绍 | The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| 生物功能 | Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. [UniProt] |
| 细胞定位 | Cell junction, focal adhesion, adherens junction. Cell membrane; Peripheral membrane protein. ER membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol, cytoskeleton. Secreted, exosome. Membrane raft. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. [UniProt] |
| 预测分子量 | 32 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine residues. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG41841 anti-Syntenin 1 antibody WB image
Western blot: HeLa cell lysate stained with ARG41841 anti-Syntenin 1 antibody.
