ARG63381
anti-Syntrophin antibody
anti-Syntrophin antibody for Western blot and Human,Mouse,Rat
Signaling Transduction antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes Syntrophin |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 预测物种 | Cow, Dog, Pig |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Syntrophin |
| 抗原物种 | Human |
| 抗原 | ASGRRAPRTGLLE-C |
| 偶联标记 | Un-conjugated |
| 別名 | dJ1187J4.5; Syntrophin-1; SNT1; LQT12; 59 kDa dystrophin-associated protein A1 acidic component 1; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; Alpha-1-syntrophin; TACIP1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 背景介绍 | Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jul 2012] |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 54 kDa |
| 翻译后修饰 | Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity). |
检测图片 (1) Click the Picture to Zoom In
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ARG63381 anti-Syntrophin antibody WB image
Western Blot: Human Muscle lysate (35 µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. stained with ARG63381 anti-Syntrophin (alpha 1) antibody at 0.01 µg/ml dilution.
