ARG45181
anti-TAB2 antibody
anti-TAB2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TAB2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TAB2 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human TAB2. |
| 偶联标记 | Un-conjugated |
| 別名 | TAB2; TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein; MAP3K7IP2; KIAA0733; Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 2; TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 2; TAK1-Binding Protein 2; TAB-2; Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2; TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein; TGF-Beta-Activated Kinase 1-Binding Protein 2; TAK1 Binding Protein 2; CHTD2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 76 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.01% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9NYJ8 Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 |
|---|---|
| 基因名称 | TAB2 |
| 全名 | TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2 |
| 背景介绍 | The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| 生物功能 | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). [UniProt] |
| 细胞定位 | Membrane; Endosome membrane; Lysosome membrane; Cytoplasm, cytosol. [UniProt] |
| 预测分子量 | 76 kDa |
| 翻译后修饰 | Isopeptide bond; Methylation; Phosphoprotein; Ubl conjugation. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG45181 anti-TAB2 antibody IHC-P image
Immunohistochemistry: Human rectal cancer stained with ARG45181 anti-TAB2 antibody at 2 μg/ml dilution.
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ARG45181 anti-TAB2 antibody WB image
Western blot: Hela, A549, and HepG2 stained with ARG45181 anti-TAB2 antibody at 0.5 μg/ml dilution.
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ARG45181 anti-TAB2 antibody FACS image
Flow Cytometry: U87 stained with ARG45181 anti-TAB2 antibody at 1 µg/10^6 cells dilution.
