ARG44560
anti-TET3 antibody
anti-TET3 antibody for IHC-Formalin-fixed paraffin-embedded sections and Mouse,Rat
Gene Regulation antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TET3 |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TET3 |
| 偶联标记 | Un-conjugated |
| 別名 | TET3; Tet Methylcytosine Dioxygenase 3; HCG_40738; Methylcytosine Dioxygenase TET3; Tet Oncogene Family Member 3; Ten-Eleven Translocation 3; MGC22014; Probable Methylcytosine Dioxygenase TET3; Putative Methylcytosine Dioxygenase; EC 1.14.11.80; EC 1.14.11.N2; KIAA0401; BEFAHRS |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TET3 |
| 全名 | tet methylcytosine dioxygenase 3 |
| 背景介绍 | Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]). [supplied by OMIM, Nov 2010] |
| 生物功能 | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. [UniProt] |
| 细胞定位 | Chromosome, Cytoplasm, Nucleus. [UniProt] |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 194 kDa |
| 翻译后修饰 | Isopeptide bond, Ubl conjugation. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG44560 anti-TET3 antibody IHC-P image
Immunohistochemistry: Mouse testis stained with ARG44560 anti-TET3 antibody at 1:200 dilution.
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ARG44560 anti-TET3 antibody IHC-P image
Immunohistochemistry: Rat colon stained with ARG44560 anti-TET3 antibody at 1:400 dilution.
