ARG52444
anti-TFAM antibody
anti-TFAM antibody for Western blot and Human,Mouse,Rat
Cell Biology and Cellular Response antibody; Controls and Markers antibody; Gene Regulation antibody; Metabolism antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TFAM |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TFAM |
| 抗原物种 | Mouse |
| 抗原 | Native recombinant mouse TFAM protein with c-terminal 6-his tag |
| 偶联标记 | Un-conjugated |
| 別名 | TCF6; MTTFA; mtTFA; TCF-6; Transcription factor A, mitochondrial; MtTF1; MTTF1; Mitochondrial transcription factor 1; Transcription factor 6-like 2; TCF6L1; Transcription factor 6; TCF6L3; TCF6L2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | Specific for the ~24 kDa TFAM protein. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Neat Serum |
| 缓冲液 | Neat serum |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TFAM |
| 全名 | transcription factor A, mitochondrial |
| 背景介绍 | Mitochondrial Transcription Factor A (TFAM) is a key activator of mitochondrial (mt) DNA transcription as well as a participant in mitochondrial genome replication. mtDNA is highly susceptible to oxidative stress leading to mitochondrial dysfunction. Overexpression of TFAM has been implicated in the amelioration of age dependent impairment of brain functions through the prevention of oxidative stress and mitochondrial dysfunction in microglia (Hayashi et al., 2008). More recently, TFAM overexpression has been shown to potentially reduce oxidative stress in motor neurons and delay onset of amyotrophic lateral sclerosis (ALS) in ALS model mice (Morimoto et al., 2012). |
| 研究领域 | Cell Biology and Cellular Response antibody; Controls and Markers antibody; Gene Regulation antibody; Metabolism antibody; Signaling Transduction antibody |
| 预测分子量 | 29 kDa |
| 翻译后修饰 | Phosphorylation by PKA within the HMG box 1 impairs DNA binding and promotes degradation by the AAA+ Lon protease. |
检测图片 (1) Click the Picture to Zoom In
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ARG52444 anti-TFAM antibody WB image
Western blot: Rat kidney lysate showing specific immunolabeling of the ~24 kDa TFAM protein stained with ARG52444 anti-TFAM antibody.
