ARG56429
anti-TGF beta 1 antibody
anti-TGF beta 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
参考文献8
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TGF beta 1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 特异性 | This antibody detects endogenous levels of TGF beta 1 protein. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TGF beta 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around aa. 341-390 of Human TGF beta 1. |
| 偶联标记 | Un-conjugated |
| 別名 | TGFB; DPD1; TGFbeta; CED; Transforming growth factor beta-1; LAP; TGF-beta-1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 纯度 | > 95% (by SDS-PAGE). |
| 缓冲液 | PBS (pH 7.2) and 0.05% Sodium azide. |
| 抗菌剂 | 0.05% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TGFB1 |
| 全名 | transforming growth factor, beta 1 |
| 背景介绍 | This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009] |
| 生物功能 | Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. [UniProt] |
| 预测分子量 | 44 kDa |
| 翻译后修饰 | Glycosylated. The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive. |
检测图片 (3) Click the Picture to Zoom In
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ARG56429 anti-TGF beta 1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human breast carcinoma tissue stained with ARG56429 anti-TGF beta 1 antibody.
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ARG56429 anti-TGF beta 1 antibody WB image
Western blot: 40 µg of 1) L02, 2) HEK293T, 3) AML-12, and 4) H9C2 whole cell lysates stained with ARG56429 anti-TGF beta 1 antibody at 1:500 dilution.
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ARG56429 anti-TGF beta 1 antibody WB image
Western blot: 1) HeLa, 2) SP2/0, 3) H9C2, and 4) MCF-7 cell lysates stained with ARG56429 anti-TGF beta 1 antibody at 1:500 dilution.
文献引用
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