ARG56894

anti-TGFBI antibody

Datasheet

参考文献4

订购信息

包装

价格 (USD)

100 μl

399

arigo in CHINA:
恩瑞科生物
☎ 400-886-0853,
0571-8708-1890

概述

产品描述	Rabbit Polyclonal antibody recognizes TGFBI
反应物种	Hu, Ms, Rat
应用	ICC/IF, IHC-P, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	TGFBI
抗原物种	Human
抗原	Recombinant fusion protein corresponding to aa. 481-683 of Human TGFBI (NP_000349.1).
偶联标记	Un-conjugated
別名	CDGG1; LCD1; RGD-CAP; CSD2; CSD; Beta ig-h3; CSD1; Transforming growth factor-beta-induced protein ig-h3; RGD-containing collagen-associated protein; BIGH3; CDG2; CSD3; Kerato-epithelin; CDB1; EBMD

应用说明

应用建议

应用	推荐稀释比
ICC/IF	1:50 - 1:200
IHC-P	1:50 - 1:200
WB	1:500 - 1:2000

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

阳性对照

Rat kidney, Mouse heart and BxPC3

实际分子量

~ 74 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 21810 Mouse TGFBI GeneID: 7045 Human TGFBI Swiss-port # P82198 Mouse Transforming growth factor-beta-induced protein ig-h3 Swiss-port # Q15582 Human Transforming growth factor-beta-induced protein ig-h3
基因名称	TGFBI
全名	transforming growth factor, beta-induced, 68kDa
背景介绍	This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
生物功能	Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. [UniProt]
细胞定位	Secreted. Secreted, extracellular space, extracellular matrix. Note=May be associated both with microfibrils and with the cell surface (PubMed:8077289). [UniProt]
预测分子量	75 kDa
翻译后修饰	Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; these residues may be required for binding to calcium (PubMed:18450759). According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833). The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain. [UniProt]

检测图片 (3) Click the Picture to Zoom In

ARG56894 anti-TGF beta 1 antibody IHC-P image

Immunohistochemistry: Paraffin-embedded Human lung cancer stained with ARG56894 anti-TGF beta 1 antibody at 1:100 dilution.
ARG56894 anti-TGF beta 1 antibody WB image

Western blot: 25 µg of Rat kidney, Mouse heart and BxPC-3 cell lysates stained with ARG56894 anti-TGF beta 1 antibody at 1:1000 dilution.
ARG56894 anti-TGF beta 1 antibody IHC-P image

Immunohistochemistry: Paraffin-embedded Human colon carcinoma stained with ARG56894 anti-TGF beta 1 antibody at 1:100 dilution.