ARG58125
anti-TIMP3 antibody
anti-TIMP3 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TIMP3 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TIMP3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 175-211 of Human TIMP3. |
| 偶联标记 | Un-conjugated |
| 別名 | HSMRK222; K222TA2; TIMP-3; Protein MIG-5; K222; SFD; Metalloproteinase inhibitor 3; Tissue inhibitor of metalloproteinases 3 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10mM Citrate buffer (pH 6.0) for 10-20 min followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS (pH 7.4) |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TIMP3 |
| 全名 | TIMP metallopeptidase inhibitor 3 |
| 背景介绍 | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008] |
| 生物功能 | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. [UniProt] |
| 细胞定位 | Cytoplasmic. [UniProt] |
| 预测分子量 | 24 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG58125 anti-TIMP3 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human placenta tissue stained with ARG58125 anti-TIMP3 antibody.
