ARG58835
anti-TRAP1 antibody
anti-TRAP1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TRAP1 |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TRAP1 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to A571-H704 of Human TRAP1. |
| 偶联标记 | Un-conjugated |
| 別名 | HSP90L; Tumor necrosis factor type 1 receptor-associated protein; TRAP-1; TNFR-associated protein 1; Heat shock protein 75 kDa, mitochondrial; HSP 75; HSP75 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: By heat mediation. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q12931 Human Heat shock protein 75 kDa, mitochondrial Swiss-port # Q5XHZ0 Rat Heat shock protein 75 kDa, mitochondrial |
|---|---|
| 基因名称 | TRAP1 |
| 全名 | TNF receptor-associated protein 1 |
| 背景介绍 | This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| 生物功能 | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. [UniProt] |
| 细胞定位 | Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix. [UniProt] |
| 预测分子量 | 80 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG58835 anti-TRAP1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human intestinal cancer stained with ARG58835 anti-TRAP1 antibody.
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ARG58835 anti-TRAP1 antibody WB image
Western blot: 50 µg of Rat cardiac muscle, 50 µg of Rat kidney, 50 µg of Rat brain, 40 µg of SMMC-7721, 40 µg of PANC and 40 µg of A549 lysates stained with ARG58835 anti-TRAP1 antibody at 0.5 µg/ml dilution.
