ARG44973
anti-TRIM72 / MG53 antibody
anti-TRIM72 / MG53 antibody for Western blot and Human,Rat
概述
| 产品描述 | Mouse Monoclonal antibody recognizes TRIM72 / MG53 |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG |
| 靶点名称 | TRIM72 / MG53 |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | TRIM72; Tripartite Motif Containing 72; MG53; Tripartite Motif Containing 72, E3 Ubiquitin Protein Ligase; Tripartite Motif-Containing Protein 72; Mitsugumin-53; Tripartite Motif-Containing 72; Mitsugumin 53; Mg53 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # A0JPQ4 Rat Tripartite motif-containing protein 72 Swiss-port # Q6ZMU5 Human Tripartite motif-containing protein 72 |
|---|---|
| 基因名称 | TRIM72 |
| 全名 | Tripartite Motif Containing 72 |
| 背景介绍 | Enables identical protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; plasma membrane repair; and protein homooligomerization. Predicted to act upstream of or within negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; and negative regulation of myotube differentiation. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in cytoplasm and sarcolemma. [provided by Alliance of Genome Resources, Apr 2022] |
| 生物功能 | Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca2+-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles. [Uniprot] |
| 细胞定位 | Cell membrane, Cytoplasmic vesicle, Membrane. [Uniprot] |
| 翻译后修饰 | Disulfide bond, Phosphoprotein, S-nitrosylation. [Uniprot] |
检测图片 (1) Click the Picture to Zoom In
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ARG44973 anti-TRIM72 / MG53 antibody WB image
Western blot: Rat skeletal muscle stained with ARG44973 anti-TRIM72 / MG53 antibody at 1 µg/mL dilution.
