ARG66806
anti-TTF1 antibody [SQab20219]
anti-TTF1 antibody [SQab20219] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant Rabbit Monoclonal antibody [SQab20219] recognizes TTF1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab20219 |
| 同位型 | IgG |
| 靶点名称 | TTF1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within aa. 50-150 of Human TTF1. |
| 偶联标记 | Un-conjugated |
| 別名 | Transcription termination factor 1; TTF-1; RNA polymerase I termination factor; Transcription termination factor I; TTF-I |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C - 25°C) for 30 minutes. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q15361 Human Transcription termination factor 1 |
|---|---|
| 基因名称 | TTF1 |
| 全名 | transcription termination factor, RNA polymerase I |
| 背景介绍 | This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011] |
| 生物功能 | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. [UniProt] |
| 细胞定位 | Nucleus. Nucleus, nucleolus. [UniProt] |
| 预测分子量 | 103 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG66806 anti-TTF1 antibody [SQab20219] IHC-P image
Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded Human thyroid tissue. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). The tissue section was stained with ARG66806 anti-TTF1 antibody [SQab20219].
