ARG66632
anti-Thyroglobulin antibody [SQab19150]
anti-Thyroglobulin antibody [SQab19150] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant Rabbit Monoclonal antibody [SQab19150] recognizes Thyroglobulin |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab19150 |
| 同位型 | IgG |
| 靶点名称 | Thyroglobulin |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within aa. 350-450 of Human Thyroglobulin. |
| 偶联标记 | Un-conjugated |
| 別名 | AITD3; Tg; TGN; Thyroglobulin |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C - 25°C) for 30 minutes. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TG |
| 全名 | thyroglobulin |
| 背景介绍 | Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009] |
| 生物功能 | Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 305 kDa |
| 翻译后修饰 | Sulfated tyrosines are desulfated during iodination. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG66632 anti-Thyroglobulin antibody [SQab19150] IHC-P image
Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded Human thyroid cancer tissue stained with ARG66632 anti-Thyroglobulin antibody [SQab19150]. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0).
