ARG59952
anti-UBASH3B / Sts1 antibody
anti-UBASH3B / Sts1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes UBASH3B / Sts1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | UBASH3B / Sts1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-300 of Human UBASH3B (NP_116262.2). |
| 偶联标记 | Un-conjugated |
| 別名 | Ubiquitin-associated and SH3 domain-containing protein B; p70; STS-1; Tyrosine-protein phosphatase STS1/TULA2; STS1; Cbl-interacting protein p70; T-cell ubiquitin ligand 2; Suppressor of T-cell receptor signaling 1; TULA-2; EC 3.1.3.48; TULA2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse brain and SW620 | ||||||||
| 实际分子量 | 73 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8BGG7 Mouse Ubiquitin-associated and SH3 domain-containing protein B Swiss-port # Q8TF42 Human Ubiquitin-associated and SH3 domain-containing protein B |
|---|---|
| 基因名称 | UBASH3B |
| 全名 | ubiquitin associated and SH3 domain containing B |
| 背景介绍 | This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008] |
| 生物功能 | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. [UniProt] |
| 预测分子量 | 73 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG59952 anti-UBASH3B / Sts1 antibody ICC/IF image
Immunofluorescence: A549 cells stained with ARG59952 anti-UBASH3B / Sts1 antibody.
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ARG59952 anti-UBASH3B / Sts1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat spleen stained with ARG59952 anti-UBASH3B / Sts1 antibody at 1:100 dilution.
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ARG59952 anti-UBASH3B / Sts1 antibody WB image
Western blot: 25 µg of Mouse brain and SW620 cell lysates stained with ARG59952 anti-UBASH3B / Sts1 antibody at 1:1000 dilution.
