ARG44765
anti-UBE3A antibody
anti-UBE3A antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes UBE3A |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | UBE3A |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | Renal carcinoma antigen NY-REN-54; E6AP ubiquitin-protein ligase; EC 6.3.2.-; Human papillomavirus E6-associated protein; E6-AP; Oncogenic protein-associated protein E6-AP; AS; Ubiquitin-protein ligase E3A; HPVE6A; EPVE6AP; ANCR |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | UBE3A |
| 全名 | ubiquitin protein ligase E3A |
| 背景介绍 | This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. [UniProt] |
| 预测分子量 | 101 kDa |
| 翻译后修饰 | Phosphorylation at Tyr-659 by ABL1 impairs E3 ligase activity and protects p53/TP53 from degradation in (HPV)-infected cells. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG44765 anti-UBE3A antibody IHC-P image
Immunohistochemistry: Human testis stained with ARG44765 anti-UBE3A antibody at 4.7 µg/mL dilution.
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ARG44765 anti-UBE3A antibody IP image
Immunoprecipitation: K562 lysate immunoprecipitated with 2.5 µg of ARG44765 anti-UBE3A antibody.
