ARG56212
anti-VEGFC antibody [197CT7.3.4]
anti-VEGFC antibody [197CT7.3.4] for Immunoprecipitation,Western blot and Human,Mouse,Rat
参考文献1
概述
| 产品描述 | Mouse Monoclonal antibody recognizes VEGFC |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 197CT7.3.4 |
| 同位型 | IgG1, kappa |
| 靶点名称 | VEGFC |
| 抗原物种 | Human |
| 抗原 | Human VEGFC recombinant protein. |
| 偶联标记 | Un-conjugated |
| 別名 | VRP; Flt4-L; VEGF-C; Vascular endothelial growth factor-related protein; Flt4 ligand; Vascular endothelial growth factor C; LMPH1D |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | 293 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | VEGFC |
| 全名 | vascular endothelial growth factor C |
| 背景介绍 | The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014] |
| 生物功能 | Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. [UniProt] |
| 细胞定位 | Secreted. |
| 预测分子量 | 47 kDa |
| 翻译后修饰 | Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. |
检测图片 (1) Click the Picture to Zoom In
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ARG56212 anti-VEGFC antibody WB image
Western blot: 35 µg of 293 cell lysate stained with ARG56212 anti-VEGFC antibody at 1:1000 dilution.
文献引用
Characteristic Features of Deep Brain Lymphatic Vessels and Their Regulation by Chronic Stress
WB/IP / Mouse
