ARG44769
anti-WWP1 antibody
anti-WWP1 antibody for Immunoprecipitation and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes WWP1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2a |
| 靶点名称 | WWP1 |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | NEDD4-like E3 ubiquitin-protein ligase WWP1; WW domain-containing protein 1; EC 6.3.2.-; Atrophin-1-interacting protein 5; Tiul1; hSDRP1; AIP5; TGIF-interacting ubiquitin ligase 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9H0M0 Human NEDD4-like E3 ubiquitin-protein ligase WWP1 |
|---|---|
| 基因名称 | WWP1 |
| 全名 | WW domain containing E3 ubiquitin protein ligase 1 |
| 背景介绍 | WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. [UniProt] |
| 细胞定位 | Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. [UniProt] |
| 预测分子量 | 105 kDa |
| 翻译后修饰 | Auto-ubiquitinated and ubiquitinated by RNF11. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG44769 anti-WWP1 antibody IP image
Immunoprecipitation: HeLa lysate immunoprecipitated with 2.5 µg of ARG44769 anti-WWP1 antibody.
