ARG44987
anti-WWP2 antibody
anti-WWP2 antibody for Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes WWP2 |
|---|---|
| 反应物种 | Hu |
| 应用 | IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2a |
| 靶点名称 | WWP2 |
| 抗原物种 | Human |
| 抗原表位 | TAVAPENRHQ PPSTNCFGGR SRTHRHSGAS ARTTPATGEQ SPGARSRHRQ PVKNSGHSGL ANGTVNDEPT TATDPEEPSV VGVTSPPAAP LSVTPNPNTT SLPAPATPAE GEEPSTSGTQ QLPAAAQAPD ALPAGWEQRE LPNGRVYYVD HNTKTTTWER PLPPGWEKRT DPRGRFYYVD HNTRTTTWQR PTAEYVRNYE |
| 偶联标记 | Un-conjugated |
| 別名 | WWP2; WW Domain Containing E3 Ubiquitin Protein Ligase2; AIP2; NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2; HECT-Type E3 Ubiquitin Transferase WWP2; Atrophin-1-Interacting Protein2; Atrophin-1 Interacting Protein2; WW Domain-Containing Protein2; EC2.3.2.26; WWp2-Like; EC6.3.2 |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O00308 Human NEDD4-like E3 ubiquitin-protein ligase WWP2 |
|---|---|
| 基因名称 | WWP2 |
| 全名 | WW Domain Containing E3 Ubiquitin Protein Ligase2 |
| 背景介绍 | This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome10. [provided by RefSeq, Jul2012] |
| 生物功能 | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. [Uniprot] |
| 细胞定位 | Nucleus. [Uniprot] |
| 翻译后修饰 | Phosphoprotein, Ubl conjugation. [Uniprot] |
检测图片 (2) Click the Picture to Zoom In
-
ARG44987 anti-WWP2 antibody WB image
Western blot: Jurkat stained with ARG44987 anti-WWP2 antibody at 1 µg/mL dilution.
-
ARG44987 anti-WWP2 antibody IP image
Immunoprecipitation: Jurkat lysate immunoprecipitated with 2.5 µg of ARG44987 anti-WWP2 antibody.
