ARG44770
anti-XIAP antibody
anti-XIAP antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes XIAP |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2a |
| 靶点名称 | XIAP |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | XLP2; MIHA; hIAP3; Baculoviral IAP repeat-containing protein 4; EC 6.3.2.-; API3; hIAP-3; hILP; ILP1; BIRC4; E3 ubiquitin-protein ligase XIAP; IAP-like protein; IAP-3; Inhibitor of apoptosis protein 3; ILP; X-linked inhibitor of apoptosis protein; X-linked IAP |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | XIAP |
| 全名 | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase |
| 背景介绍 | BIRC-4 (for baculoviral IAP repeat-containing protein 4) is a member of the IAP (for Inhibitor of apoptosis protein) family proteins. Other Aliases include RP1-315G1.5, API3, ILP1, MIHA, XIAP, XLP2. BIRC4 inhibits activated caspase-3 and apoptosis. |
| 生物功能 | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG44770 anti-XIAP antibody IHC-P image
Immunohistochemistry: Human colon stained with ARG44770 anti-XIAP antibody at 5 µg/mL dilution.
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ARG44770 anti-XIAP antibody WB image
Western blot: MCF, HeLa, HT-29 stained with ARG44770 anti-XIAP antibody at 1 µg/mL dilution.
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ARG44770 anti-XIAP antibody IP image
Immunoprecipitation: HeLa lysate immunoprecipitated with 2.5 µg of ARG44770 anti-XIAP antibody.
