ARG62662
anti-XPF antibody [51]
anti-XPF antibody [51] for Western blot and Human
Gene Regulation antibody
概述
| 产品描述 | Mouse Monoclonal antibody [51] recognizes XPF |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 51 |
| 同位型 | IgG2b, kappa |
| 靶点名称 | XPF |
| 抗原物种 | Human |
| 抗原 | Recombinant full length protein (Human). |
| 偶联标记 | Un-conjugated |
| 別名 | DNA repair protein complementing XP-F cells; Xeroderma pigmentosum group F-complementing protein; FANCQ; XPF; EC 3.1.-.-; DNA repair endonuclease XPF; ERCC11; RAD1; DNA excision repair protein ERCC-4 |
应用说明
| 应用说明 | WB: use a concentration of 1 - 2 µg/ml * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|---|
| 阳性对照 | MCF-7 cells |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purified |
| 缓冲液 | 10mM PBS (pH 7.4), 0.2% BSA and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 0.2% BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ERCC4 |
| 全名 | excision repair cross-complementation group 4 |
| 背景介绍 | XPF/ERCC4 is suggested to play a role in the repair of DNA double-strand breaks (DSB), homologous recombination, and gene conversion via single-strand annealing (SSA). XPF/ERCC4 is an endonuclease that incises 5-prime DNA. Defects in XPF/ERCC4 cause xeroderma pigmentosum VI (XP6) an autosomal recessive disease characterized by hypersensitivity to sunlight and a predisposition to skin cancer as well as neurological abnormalities. Defects in XPF/ERCC4 are also responsible for XFE progeroid syndrome, a syndrome characterized by dwarfism, cachexia, and microcephaly. |
| 生物功能 | Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. [UniProt] |
| 细胞定位 | Nucleus |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 104 kDa |
克隆号文献
Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step.
BL / Human
gamma-H2AX formation in response to interstrand crosslinks requires XPF in human cells.
WB / Human
Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity.
WB / Human
