ARG23703
anti-p15 INK4b antibody [DCS114.1]
anti-p15 INK4b antibody [DCS114.1] for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [DCS114.1] recognizes p15 INK4b |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | DCS114.1 |
| 同位型 | IgG1 |
| 靶点名称 | p15 INK4b |
| 抗原物种 | Human |
| 抗原 | A his-tagged recombinant full length p15 protein. |
| 偶联标记 | Un-conjugated |
| 別名 | MTS-2; MTS2; Multiple tumor suppressor 2; p14-INK4b; Cyclin-dependent kinase 4 inhibitor B; TP15; p15INK4B; p15-INK4b; P15; p15INK4b; CDK4I; INK4B |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A/G. |
| 缓冲液 | PBS and 0.08% Sodium azide. |
| 抗菌剂 | 0.08% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P42772 Human Cyclin-dependent kinase 4 inhibitor B |
|---|---|
| 基因名称 | CDKN2B |
| 全名 | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
| 背景介绍 | This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] |
| 生物功能 | Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. [UniProt] |
| 预测分子量 | 15 kDa |
